md-medicaldata

Authors

 

Milana Bosanac¹, Vanja Tovilović², Jelena Ilić Sabo ^1,2, Bojana Andrejić-Višnjić ¹, Nevena Stanulović^1,3, Ivanka Perčić² , Bosiljka Krajnović<sup>4

1</sup>Medicinski fakultet, Univerzitet u Novom Sadu, Srbija
²Klinički centar Vojvodine, Novi Sad, Srbija
²Institut za onkologiju Vojvodine, Sremska Kamenica, Srbija
²Institut za plućne bolesti Vojvodine, Sremska Kamenica, Srbija

 

UDK: 572.51-053.6
613.71/.74-053.6

The paper was received / Rad primljen: 29.10.2021.

Accepted / Rad prihvaćen: 15.12.2021.

 

Correspondence to:

doc. dr Jelena Ilić Sabo
Medicinski fakultet Univerziteta u Novom Sadu, Srbija
Hajduk Veljkova 3, 21000 Novi Sad, Srbija
telefon: +38163303585
e-mail: jelena.ilic-sabo@mf.uns.ac.rs

 

 

Sažetak

 

Uvod: Limfni čvorovi imaju ulogu filtriranja limfe, te sprečavanja daljeg širenja infekcije/tumora. Metastaze predstavljaju širenje tumora sa primarnog mesta nastanka tumora. Karcinom kolona je jedan od najčešćih malignih tumora. Ciljevi istraživanja su bili: izmeriti veličinu limfnog čvora, odrediti broj primarnih i sekundarnih limfoidnih folikula, izračunati njihov odnos u svakom limfnom čvoru. Semikvantitativno proceniti broj blasta u germinativnom centru sekundarnih limfoidnih folikula, proceniti proširenost sinusa, sinus histiocitozu i hiperemiju. Kao i ispitati stepen korelacije između navedenih parametara. Materijal i metode: Sprovedena je retrospektivna studija. Podaci su dostavljeni u Centar za patologiju i histologiju sa Klinike za abdominalnu hirurgiju Kliničkog Centra Vojvodine. Analizirano je 50 regionalnih, reaktivno izmenjenih limfnih čvorova. Parametri su ocenjivani semikvantitativno, a rezultati su statistički obrađeni u programima  Microsoft office Excel 2010 i Social Science Statistics. Rezultati: Prosečni dijametar reaktivno izmenjenih regionalnih čvorova je 5,23 mm. U 70% čvorova prosečan broj blasta se kreće između 1 i 5. U 54% čvorova uočava se izražena ravnomerna proširenost sinusa. U 48% analiziranih limfnih čvorova prisutan je umeren broj histiocita u sinusima. Hiperemija je odsutna u 42% analiziranih limfnih čvorova. U 62% ispitanih slučajeva nalaze se samo reaktivno izmenjeni limfni čvorovi. Korelacija varira u zavisnosti od poređenih parametara.  Zaključak: U regionalnim, reaktivno izmenjenim limfnim čvorovima uočavaju se promene u vidu proširenosti sinusa, sinus histiocitoze, hiperemije i povećanog broja sekundarnih limfoidnih folikula sa povećanim brojem blasta u germinativnim centrima. Među pojedinim poređenim parametrima uočavamo značajnu korelaciju, dok kod nekih ne postoji.

 

Ključne riječi

limfni čvor; karcinom kolona; metastaza

 

 

 

Abstract

 

Introduction: Lymph nodes have the role of filtering the lymph, and preventing the further spread of infection / tumor. Metastases are the spread of a tumor from the primary site of tumor formation. Colon cancer is one of the most common malignant tumors. The aims of the study were: to measure the size of the lymph node, to determine the number of primary and secondary lymphoid follicles, to calculate their ratio in each lymph node. Semiquantitatively assess the number of blasts in the germinal center of secondary lymphoid follicles, assess sinus dilatation, sinus histiocytosis and hyperemia. As well as to examine the degree of correlation between the stated parameters. Material and methods: A retrospective study was conducted. The data were submitted to the Center for Pathology and Histology from the Clinic for Abdominal Surgery of the Clinical Center of Vojvodina. 50 regional, reactively altered lymph nodes. The parameters were evaluated semiquantitatively, and the results were statistically processed in Microsoft office Excel 2010 and Social Science Statistics. Results: The average diameter of reactively altered regional nodes is 5.23 mm. In 70% of nodes, the average number of blasts ranges between 1 and 5. In 54% of nodes, a pronounced uniform expansion of the sinuses is observed. A moderate number of histiocytes in the sinuses is present in 48% of the analyzed lymph nodes. Hyperemia is absent in 42% of analyzed lymph nodes. In 62% of the examined cases, there are only reactively altered lymph nodes. The correlation varies depending on the compared parameters. Conclusion: In regional, reactively altered lymph nodes, changes in the form of sinus dilatation, sinus histiocytosis, hyperemia and increased number of secondary lymphoid follicles with increased number of blasts in germinal centers. We notice a significant correlation between some of the compared parameters, while some do not. 

Key words:

lymph node; colon cancer; metastasis

 

 

 

 

References:

1. Mescher AL.  Junqueira’s Basic Histology TEXT AND ATLAS. 14th edition. New York: Mc Graw Hill Education; 2016; 282-5.
2. Bazemore AW, Smucker DR. Lymphadenopathy and malignancy. Cincinnati, Ohio : University of Cincinnati College of Medicine; 2002.
3. Mayo clinic [Internet].  Scottsdale/Phoenix: Mayo Foundation for Medical Education and Research; c1998-2021 [cited 2021 Nov 22]. Swollen lymph nodes; [about 4 screens]. Available from: https://www.mayoclinic.org/diseases-conditions/swollen-lymph-nodes/symptoms-causes/syc-20353902
4. Ioachim HL, Medeiros LJ. IOACHIM’S Lymph Node Pathology. 4th edition. Philadelphia: Lippincott Williams & Wilkins, a Wolters Kluwer business; 2009; 590-5.
5. Gadday HL, Reigel AM. Unexplained lymphadenopathy: evaluation and differential diagnosis. Nebraska : Ehrling Bergquist Family Medicine Residency Program, Offutt Air Force Base; 2016.
6. Indranil M, Doru P. The Role of T-Cells in Cancer.Verywell Health [Internet]. 2020 Jun [cited 2021 Nov 22]; [about 1 p.]. Available from: . https://www.verywellhealth.com/t-cells-2252171.
7. Fisher ER, Saffer E, Fisher B. Studies concerning the regional lymph node in cancer. VI. Correlation of lymphocyte transformation of regional node cells and some histopathologic discriminants. Cancer. 1973; 32(1):104-11.
8. Miranda RN, Medeiros LJ, Khoury JD. Atlas of Lymph Node Pathology. New York: Springer; 2013.
9. Espino M, Peace S. Colon and Rectal Cancers. FCDS 2013-2014 Educational Webcast Series; 2013.
10. Taylor CR, Wang SY, Pfeifer KE. Colon Cancer Imaging. Medscape Medical News; 2017.
11. Nesbakken A. Histology of colon and rectum cancer. Oslo: Oncolex; 2015.
12. Netter FH,  Reynolds JC. The Netter collection of medical illustrations – Digestive system part II – lower digestive tract. Philadelphia: Elsevier; 2017; 9(2).
13. Weisenberg E. Colon general staging carcinoma. PathologyOutlines.com, Inc. 2017-20.
14. Nelson R. Lymph Node Removal Ups Survival in Right-Sided Colon Cancer. Medscape Medical News; 2018.
15. Dudea SM, Lenghel M, Botar – Jid C, Vasilescu P, Duma M. Ultrasonography of superficial lymph nodes: benign vs. malignant. Med Ultrason. 2012; 14(4):294-306.
16. Markl B, Rosle J, Arnholdt HM, Schaller T, Krammer I, Cacchi C et al. The clinical significance of lymph node size in colon cancer. Modern Pathol. 2012; 25:1413–22.
17. Dire JJ, Lane N. The relation of sinus histiocytosis in axillary lymph nodes to surgical curability of carcinoma of the breast. Am J Clin Pathol. 1963; 40( 5):508-15.
18. Manfro G, Cernea C, Silvestre de Faria PA, Vaz Agarez F, Luiz Diaz F, Araujo Lima R et al.  Can the lymph node reactivity pattern in the pN0 neck analysis provide any additional prognostic information in patients with laryngeal squamous cell carcinoma? Study carried out at Instituto Nacional do Câncer – INCA, Rio de Janeiro (RJ), Brazil; 2010.
19. Das S, Sarrou E, Podgrabinska S, Casella M, Mungamuri SK, Feirt N et al.  Tumor cell entry into the lymph node is controlled by CCL1 chemokine expressed by lymph node lymphatic sinuses. J Experiment Med. 2013; 210(8):1509-28.
20. Yamamoto C, Yuasa K, Okamura K,  Shiraishi T,  Miwa K. Vascularity as assessed by Doppler intraoral ultrasound around the invasion front of tongue cancer is a predictor of pathological grade of malignancy and cervical lymph node metastasis. Fukuoka, Japan: Section of Image Diagnostics, Department of Diagnostics and General Care, Fukuoka Dental College; 2016.
21. Acharya S, Kumari N, Srivastava P, Arnold D, Nikhril K. Architectural changes in the regional lymph nodes of oral squamous cell carcinoma. Dharwad, Karnataka, India: Departments of Oral Pathology and Microbiology, Public Health Dentistry, S.D.M College of Dental Sciences and Hospital, A Constituent Unit of Shri Dharmasthala Manjunatheswara University; 2018.
22. Kapoor C, Vaidya S, Wadhwan V, Malik S. Lymph node metastasis: A bearing on prognosis in squamous cell carcinoma. Indian J Cancer. 2015; 52(3):417-24.
    

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